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Hyperandrogenism, characterized by elevated androgen levels and typical of PCOS, is often exacerbated by increased ovarian androgen production

While cryopreservation is effective, it poses significant challenges for sperm cells due to the physical and chemical stresses involved

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Conversely, granulosa cells show reduced GPx4 expression and ferritinophagy-mediated iron overload, leading to heightened susceptibility to ferroptosis and impaired oocyte quality ( Therapeutic approaches targeting these pathways have been explored

Myo-inositol trispyrophosphate (ITPP) was declared prohibited in 2012