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With increased iron supplementation, tissue iron concentrations rise, potentially exceeding the bodys binding capacity, leading to the formation of non-transferrin-bound iron (NTBI)

With respect to this former issue, a significant number of patients with hypothyroidism are either undertreated or overtreated

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It works through two mechanisms: inhibiting the enzyme tyrosinase (which is essential for melanin synthesis) and shifting the melanin production pathway from eumelanin (darker pigment) to pheomelanin (lighter pigment)

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