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Another theory is that the anaerobic bacteria responsible for developing Acne called Propionibacterium acnes feeds on Vit B12

It was also shown to exert detrimental effects on certain cholesterol esters and acylcarnitines

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However, the research paradigm in this field has long been dominated by animal-derived EVsthose obtained from human body fluids or mammalian cell models (Luis-Calero et al., 2024