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Its abnormal glycosylation modification (such as lack of N-glycosylation or insufficient O-glycosylation) can lead to hENT1 membrane localization disorder (endoplasmic reticulum degradation or intracellular retention) or decreased stability (accelerated protease degradation) (Chakraborty et al., 2018), thereby reducing gemcitabine influx and activation

doi: 10.3389/fendo.2013.00093 26 AbellaVScoteceMCondeJPinoJGonzalez-GayMAGomez-ReinoJJet al

Rigorous and frequent blood glucose monitoring would be an absolute necessity in any research protocol

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