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Nevertheless, with advances in synthetic biology and microbiomics, engineered bacteria as live drugs have immeasurable potential in precisely regulating the gutliver axis

Originally isolated from a protein found in human gastric juice, this peptide has attracted significant attention in preclinical research due to its potential roles in supporting tissue repair and cellular integrity

The potential molecular mechanisms underlying these effects included disturbances in redox homeostasis (as evidence by the enhanced production of ROS and reactive nitrogen species), failure of enzymatic and nonenzymatic cytoprotective mechanisms involving the glutathione system as well as nuclear factor kappa B (NF-B) and fibroblast growth factor 2-mediated pathways, and impaired mitochondrial function

Journal of Neurochemistry, 2006

Preferential activation of midbrain dopamine neurons by appetitive rather than aversive stimuli