The predicted translation products were aligned using the R package Biostrings v2.52.0, with BLOSUM100 as the score matrix, and alternative aa sequences were defined by comparing the predicted aa sequence of each mRNA isoform with that of the reference (canonical) mRNA, taking as reference the longest and/or most prevalent mRNA isoform in islets (alternative sequence generation filter)
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Treatment with corticosteroids is controversial, but intravenous immunoglobulin (IVIG) therapy alone or in combination with corticosteroids has shown varying degrees of success
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