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Endocrinol.2000,143, 543 43

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212 NAMPT inhibition increases Axin expression, which induces -catenin degradation

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The endogenous lens hromofore, tryptophan metabolites (kynurenine, 3-hydroxykynurenine, 3-hydroxykynurenine glucoside), which are relatively inert photochemically, during oxidative stress and/or aging are formed photochemically active tryptophan metabolite (N-formyl-kynurenine, xanthurenic acid) that have photochemical properties, and also act as an endogenous photosensitizers in the lens 53