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Bone loss during the fat loss period (fat loss model in obese rats) Experimental Design: Animals: Obese SD rats induced by high-fat diet were randomly divided into an obesity control group, a simple weight loss group (30% calorie restriction), and a weight loss+AOD 9604 group (500 g/kg/day)

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The role of mitochondrial oxidative stress in aging

Bioinformatics analysis (UbiBrowser) and literature mining were used to predict potential FBXO22-regulated targets, including KDM4A, p53, CD147, PTEN, BAG3, LKB1, KLF4, BACH1, Snail, and HDM2