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doi:10.1089/ARS.2009.2695 9

17: 4302 Brown AK, Cevik N

Chaichit S, Sato T, Yu H, Tanaka Y-K, Ogra Y, Mizoguchi T

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This strategy has been applied to dulaglutide, where two GLP-1 molecules are fused to the Fc fragment of IgG4, increasing the half-life while reducing the renal elimination due to the increased molecular weight