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GIP also appears to have direct effects on adipose tissue, potentially improving the way fat cells respond to metabolic signals

It is difficult to get enough carnitine via an oral dose to have a storng effect on fat break down

Vegetarians and vegans may have low dietary intake since B12 comes almost entirely from animal products

Less supported scenario: If your B12 status is already normal, extra B12 has not been shown to consistently boost energy in otherwise healthy people

A review of 12 available trials found a median sample size of just 48 participants and noted that eight of the twelve studies were funded by clinics selling the injections a significant source of bias