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Study Assumption and Market Definition 1.2

Carnitine plays a role in transporting fatty acids across the inner mitochondrial membrane for -oxidation

In insulin resistance, the body does not respond to the increasing insulin levels, therefore causing the excess glucose in the blood to be taken up by the liver and converted to fat, increasing overall fatty tissue

More recently, hypoxia-inducible factor prolyl hydroxylase inhibitors (HIF-PHIs) have received clinical approval for their ability to promote hematopoiesis through enhancing endogenous EPO production (McCallum et al., 2022)

Hence, investigation of the possible effects of LA on the development of fatty liver due to genetic mutations would expand the range of LA utilization to such cases