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6 However, GLP-1 receptor agonists and gut-derived GLP-1 do not cross the bloodbrain barrier and cannot access GLP-1 receptors in the brain parenchyma, which can only be accessed by brain (pre-proglucagon neuron)-derived GLP-1

Body weight considerations The Phase 2 clinical trial used fixed doses regardless of body weight

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Scientific Background Synthetic peptides have become essential tools in modern biochemical and biomedical research due to their ability to interact selectively with cellular targets