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The compounding industry argued, not unreasonably, that the restrictions had driven patients toward unregulated gray-market sources: overseas chemical suppliers operating under "research use only" labels with no quality controls, no dosage verification, and no pharmaceutical oversight

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Additionally, MSCs from dental tissues, such as periodontal ligament stem cells (PDLSCs), dental follicle stem cells (DFSCs) and stem cells from exfoliated deciduous teeth (SHEDs), demonstrate superior osteogenic differentiation and mineralization potential which are proven not to be inferior to BMSCs

These findings have positioned GHK-Cu as a significant subject in regenerative, dermatological, and connective tissue research models