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Generally, after 812 weeks of continuous use, a 4-week washout period is required to avoid tolerance from long-term continuous use

Further mechanistic studies are needed to determine how LA regulates the MLC pathway through potentially MLCK and/or ROCK inhibition (Fig

Together, these findings suggest that G/D-CuP promotes macrophage polarization toward the M2 phenotype, thereby reducing inflammation, enhancing antioxidant capacity, and ultimately accelerating effective wound healing