Oral acute toxicity, influence on the gastrointestinal microbiota and in vivo anti-salmonellosis effect of zizyphus lotus (L.) and Ruta chalepensis (L.) essential oils
GHK-Cu has been reported to influence mesenchymal stem cell differentiation and proliferation, raising the possibility that some of its tissue repair effects operate through stem cell recruitment and activation rather than solely through direct effects on mature cells
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Sepesi B, Zhou N, William WN Jr, Lin HY, Leung CH, Weissferdt A, Mitchell KG, Pataer A, Walsh GL, Rice DC, Roth JA, Mehran RJ, Hofstetter WL, Antonoff MB, Rajaram R, Negrao MV, Tsao AS, Gibbons DL, Lee JJ, Heymach JV, Vaporciyan AA, Swisher SG , Cascone T
Once in the cytoplasm, it binds and stabilizes KEAP1, thus interfering with NRF2 stabilization