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Bennett, O

mtDNA haplogroup J carriers have shown reduced consumption of oxygen and diminished production of ATP and ROS than non J variants, 125 whereas haplogroup H carriers demonstrate higher mitochondrial oxidative damage, oxygen consumption and ROS production

The committee will provide a recommendation, which is not FDA approval or an endorsement of its effectiveness

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Second, the microbial landscape exhibits considerable inter-individual variation, suggesting that a universal OA microbiome signature may not exist, and interventions would likely require personalization (29)