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In deeply anaesthetised rats (placed in ventral position) the tail was transected with a surgical scalpel 3 cm from the tip (and submerged into a tube with 15 ml of saline at room temperature in vertical position) and the duration and amount of bleeding were measured to evaluate the hemostatic effect of the agents or saline administration

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(2021) recently uncovered a larger rigid core for purified PrP fibrils from hamster brains, composed of residues 95227, with a structural arrangement that differs from structural models of non-infectious fibrils

doi: 10.3389/fphar.2021.621247

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