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Gastroenterology 159(6):2146-2162.e33, 2020

Collectively, this approach was designed to provide a comprehensive, balanced, and mechanistically coherent synthesis of the existing evidence, while acknowledging variability in study quality, extract standardization, and clinical methodology across the literature

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(2) intravenous administration of sodium bicarbonate to counteract metabolic acidosis, increase the ionization of salicylate in the kidneys, and thereby enhance the rate of excretion of salicylate