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Tumor endothelial cells also show reduced expression of leukocyte binding molecules, including ICAM-1 and 2, VCAM-1, E-selectin and CD34, leading to reduced response to inflammatory signals and defective recruitment of immune cells (28, 29)

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Wisconsin medical journal , 93(5), 203205

Senolytic to optimise cellular aging

Potential benefits of using GLP-1 receptor agonists after gastric sleeve surgery include: Enhanced weight loss : Observational studies suggest post-bariatric patients using GLP-1 receptor agonists may achieve additional weight reduction, typically around 510% of body weight, though individual responses vary considerably Improved glycaemic control : Particularly beneficial for patients with type 2 diabetes or prediabetes, as GLP-1 agonists enhance insulin secretion and reduce blood glucose levels Reduced appetite : These medications can help patients who struggle with persistent hunger despite surgical intervention Cardiovascular benefits : Semaglutide has demonstrated cardiovascular risk reduction in people with established cardiovascular disease, which may benefit eligible post-bariatric patients with this specific risk profile Maintenance of weight loss : May help prevent weight regain during the critical maintenance phase Potential risks and considerations include: Gastrointestinal side effects : Nausea, vomiting, diarrhoea, and constipation are common, particularly during dose escalation