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The reference point is Lipinskis Rule of 5, an empirical framework from 1997 thats become one of the most cited ideas in drug research

cAMP binds PKA, causing the regulatory subunits to dissociate from the catalytically active subunits, resulting in increased activity of the enzyme (60)

Because a large number of comparisons were performed on the relative abundance data, main effect results from these analyses also underwent a BenjaminiHochberg false discovery rate (FDR) correction for multiple comparisons, and instances where a result was significant after this correction have been duly noted

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