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If nausea, vomiting, or diarrhea remain significant at any dose, hold that dose for an additional two to four weeks before escalating

Critchley JAJH, Critchley LAH, Anderson PJ, Tomlinson B: Differences in the single-oral-dose pharmacokinetics and urinary excretion of paracetamol and its conjugates between Hong Kong Chineese and Caucasian subjects

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