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Intriguingly, SELENOT expression was upregulated in response to senescence, suggesting a stress-sensing redoxin function

It is extremely easily oxidized to disulfide bonds, forming inactive oxidized glutathione (GSSG)

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have shown that statins decrease the infiltration of the central nervous system (TH1 cell) with inflammatory cells, reduce the expression of major histocompatibility complex II (MHC-II) and inhibit CD40, CD80, and CD86

This translates to approximately 1.6 to 4 mcg per kilogram of body weight, extrapolated from effective rat doses using standard interspecies scaling factors