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Type I IFNs act as a secondary signal to repress Cyp51a1 expression, leading to the accumulation of lanosterol, a precursor in the cholesterol biosynthetic pathway

Therefore, the conjunction of the immune checkpoint inhibitors to modulators of lipid peroxidation can have additive effect on immune responses and on the impact on tumour [278]

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doi: 10.1111/REGO.12494 222 ChristensenTJensenMDKluthMKristinssonGHLynggaardKLgreidPet al