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After DNA cleavage, the miRNA hybridises with a detection hairpin immobilised on a graphene oxide electrode, which produces an ECL signal that can be quantitatively measured [112, 114, 115]

Boillee, S

Hence, elevated oxidative stress in the cornea is likely not a result of aging or cumulative DNA damage [71] but rather thought to be partly attributed to acquired defects in mitochondrial function or ROS-scavenging abilities, leading to broad cellular stress in the corneal stroma, decreased collagen expression, keratocyte loss, and, ultimately, corneal thinning [72]

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JCI Insight 5 , e140532 (2020)