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Ultra-fast responders, representing perhaps 20-30% of users, notice improvement within the first 1-3 days

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*Correspondence: Weina Li, [email protected] Meng Li, [email protected] These authors have contributed equally to this work This article was submitted to Drug Metabolism and Transport, a section of the journal Frontiers in Pharmacology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Nothing here is exotic sterile technique and accurate measurement matter far more than any single tool, and a fixed combination cannot be titrated component-by-component