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The mechanisms behind this increased risk are multifactorial: Iron and Estrogen Synergy: In breast tissue, iron synergizes with estrogen metabolites to generate reactive species, a process intensified in post-menopause when iron stores rise

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Dihexa able to dramatically augment the ability of HGF to activate c-Met by phosphorylation in HEK293 cells ( Figure 17) and stimulate MDCK cell scattering ( Figure 18)