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Remarkably, NIF also improved rat diabetic nephropathy by inhibiting pro-inflammatory cytokine production, oxidative stress, and NF-B activation in diabetic kidneys (Elsherbiny et al

-Carotene increases protein expression of nuclear NRF2 and upregulates downstream targets containing antioxidant response elements (ARE) such as NADPH quinone oxidoreductase 1 (NQO1) and haeme oxygenase-1 (HO-1), thereby reducing oxidative damage to neurons 142

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Clin Cancer Res 9:32883293