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34,35 However, the controversy surrounding the possible benefits of GIPR agonism stems from two main observations: its impaired insulinotropic effects, 36,37 and the prevention of weight gain by suppression of endogenous GIP-induced adipogenesis, 38,39 However, these seemingly discouraging observations have been questioned by the finding of the central anorexic effects of GIP, 4042 and benefits of the GLP-1R/GIPR dual agonist LY3298176 (tirzepatide) in diabetic and overweight individuals

By contrast, controlled utilization of lactate, such as lactate post-conditioning, has been demonstrated to exert neuroprotective effects in cerebral IRI (156)

This helps alleviate depressive fatigue and normalizes circadian rhythms, often disrupted in depression

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Consistent use promotes sustained energy, enhanced focus, and long-term wellness