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Description

The depletion in GSH in dopaminergic SN neurons leads to decreased E1 activity and subsequent UPP disturbance [67]

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A consultation with our medical team is required to determine if this therapy is appropriate for you.

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IGF-1 regulates dopamine release from these neurons, and the absence of IGF-1 in dopaminergic neurons decreases dopamine levels in the striatum, leading to deficits in dopamine neuron firing, spontaneous locomotion, and exploratory and learning behaviors (53)

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