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When the concentration of Ca 2+ in the cytoplasm reaches a certain level, the calcium storage pool in the endoplasmic reticulum also releases Ca 2+ , inducing ERS ( 2+ , increasing the permeability of the endoplasmic reticulum membrane by promoting redox modification of Ca 2+ channels, leading to the release of Ca 2+ reserves from the endoplasmic reticulum into the cytoplasm and inducing Ca 2+ overload ( 2+ overload regulates NADPH oxidase (NOX) and the electron transport chain (ETC) in mitochondria to promote ROS production (92)

The food particles are foreign to the body and are confused as pathogens

Figure 12 3.6.4 Metabolic pathway enrichment analysis As shown in Figure 13 , preliminary analysis and found that the main difference pathways between FI group and NC group were Autophagy-other, Autophagy-animal, Glycosylphosphatidyylinositol (GPI)-anchor biosynthesis, Glycerophospholipid metabolism