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Beyond their established role as energy substrates, SCFAs act as localized and systemic signaling molecules through G protein-coupled receptors (GPR41, GPR43, and GPR109A), thereby mediating bidirectional communication between the gastrointestinal tract and peripheral organs 165

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We next investigated hepatic GSH metabolism as GSH plays an important role in acrolein detoxification [29,33] as well as regulation of tissue redox homeostasis [16]