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This distinction matters because it means the specific formulation dispensed has not undergone the same approval process as mass-manufactured pharmaceuticals

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Batch-specific purity testing is performed using analytical methods such as HPLC and mass spectrometry, with documentation available where applicable

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Studies in mice also indicated that oxidative stress induced by selenium deficiency could result in changes in the viral genome, such as to convert a relatively harmless strain of coxsackie virus B3 into a myocarditis-causing strain (56)