Han L, Zhang Q, Shi C, Leverson JD, Dail M, Phillips DC, Chen J, Jin SS, Jacamo RO, Daver N, Jabbour EJ, Kantarjian HM, Andreeff M , Sampath D, Konopleva M
SLC15A4 mediates M1-prone metabolic shifts in macrophages and guards immune cells from metabolic stress
We found that cells supplemented with cysteine were able to restore glutathione levels and reverse the depletion caused by Bd infection
These compounds are able to react with dangerous oxidants and keep cells and tissues healthy
However, the study observed some variation in the potential of PNC-27 across different leukemia cell lines, which may be related to differences in HDM-2 isoform expression or other cellular factors that are not yet fully elucidated