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Discussion Contrasting effects of l-carnitine and d-carnitine on lipid metabolism Although carnitine has been used as a feed additive for more than 20 years, the specific effects of l- and d-carnitine in many aquatic species have yet to be properly determined ( Reference Torreele, Sluiszen and Verreth 42 Reference Selcuk, Tiril and Alagil 47 )
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However, the lack of targeting of PLGA NPs and the wide variation in brain uptake efficiency by different routes of administration limit the therapeutic efficacy of loaded drugs
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