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A substantially weaker Cu(II)-binding ligand NTA ( K D = 1.99 10 11 M at pH = 7.4 31 ) also demetallated CuHSA with the half-life of 2025 min

Lu, Differential regulation of gamma-glutamylcysteine synthetase heavy and light subunit gene expression

Research has documented maintained biological activity at room temperature for extended periods, providing experimental flexibility not possible with most research peptides

A direct comparative analysis elucidates how these agents may be positioned rationally as adjunctive or alternative interventions depending on clinical phenotype, biological vulnerability, and therapeutic goals