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This mechanism plays a critical role in the cellular response to oxidative stress and the regulation of antioxidant gene expression, and it may also be significant in disease progression [148]

By regulating the balance between excitatory and inhibitory neurotransmitters, exercise helps prevent neuronal damage and supports overall brain health [122]

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Abbreviations GSVs GLUT4-storage vesicles PM plasma membrane TIRFM total internal reflection fluorescence microscopy Competing Interests The authors declare that there are no competing interests associated with the manuscript

doi: 10.3389/fpls.2019.01115 42 LarsonR