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This inflammation harms blood vessels in the area causing them to dilate and rendering them hyperpermeable, or leaky, releasing plasma* into the surrounding tissue

Hypoxia a key regulatory factor in tumour growth

doi: 10.1016/j.neo.2015.08.005 134 GandhiNDasGM

GPX4 is required for repression of both canonical CASP1- and non-canonical CASP11-mediated cleavage of GSDMD 56 , indicating that GSH-dependent antioxidant systems do not only inhibit inflammasome assembly but also limit the oxidized membrane environment that favors gasdermin pore formation

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