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Morning or post-workout administration can also be effective, especially if done on an empty stomach to avoid insulin interference

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This section examines how mitochondrial metabolism contributes to therapeutic resistance across chemotherapy, targeted therapy, and immunotherapy, and considers its potential as a clinically relevant target for intervention (Fig

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Phase II trials showed reduced injury markers during surgery (Orhan et al., 2006) and, notably, a significant reduction in infarct size and improved myocardial salvage when combined with nitrates in acute STEMI patients undergoing primary PCI [NACIAM trial (Pasupathy et al., 2017)], suggesting potential utility in the acute setting, possibly by enhancing endogenous defenses