Priority research needs include large-scale randomized controlled trials to establish efficacy and safety, dose-ranging studies to optimize treatment protocols, long-term safety studies particularly regarding cancer risk, and comparative effectiveness research with established therapies
Mol Cancer Ther 9, 336346, 10.1158/1535-7163.MCT-09-0589 (2010)
Its also worth noting that other studies have NOT found any higher risk of brain development issues at higher serum B12 levels (quite the opposite actually)
These technologies may balance the efficacy and risk through targeting selection (single target/multiple targets, structurally similar targets, undruggable targets, active/non-active sites on targets, protein/PPI), the mode of action on targets (clearance, inhibition, or activation), and the duration and intensity of drug targets
Choose both if: You want comprehensive antioxidant protection across all fronts