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People with normal liver function store 50% of their vitamin B12 in their liver, so if your liver is not functioning properly, you may need more vitamin B12 shots than those whose livers are working as designed

However, when very high oral doses are taken, approximately 1% can be absorbed through passive diffusion, independent of intrinsic factor, which explains how mega-doses can still raise serum levels

GHK-Cu modulates gene expression in fibroblasts to increase collagen production

In primary care, this typically involves calculating a fibrosis risk score such as the FIB-4 or NAFLD fibrosis score