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Epidemiol Rev, 2001, 23:72-81

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For instance, scheduling thrombolytic therapy to coincide with peak permeability could reduce hemorrhagic complications (163, 164), while nanocarrier-based systems show enhanced BBB penetration during specific circadian windows (165, 166)

These effects are typically felt within the first 20-day cycle

Moreover, lower renal function correlates with less effective dynamic cerebral autoregulation in acute ischemic stroke, predicting a bad outcome (Castro et al., 2018)