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In addition, detoxification genetic polymorphisms (eg, CYP1A1, GSTM1, NQ01) and biomarker evaluation of oxidative stress may be considered, which include blood or urine indices such as lipid peroxides, superoxide dismutase, F2 isoprostanes, and 8-OH deoxyguanosine.16 Dietary Patterns and Nutrient Deficits In addition to exploring markers of oxidative stress, RDs also should evaluate clients dietary patterns and possible nutrient deficiencies, as the brain is an organ dependent on a constant supply of nutrients

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