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Process of maturation to Pro-IGF- requires glucose regulating protein 94 (GRP94) that possesses chaperone activity towards IGF-I

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Relevant studies have found that in NK cells of CHB patients, the upregulation of inhibitory receptors NKG2A, TIM-3, Toll-like receptor 2 (TLR2), CD94, and PD-1, as well as the decreased secretion of tumor necrosis factor- (TNF-) and IFN-, are factors that promote the occurrence and development of HCC (Figure 2) [5456]