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Donovan, J.L

Some systematic reviews and meta-analyses have found that berberine significantly improves lipid profiles, with a decrease in total cholesterol, LDL, and triglycerides, while slightly increasing HDL

However, if the goal is specifically treating post-acne marks, sun spots, or melasma patches defined areas of hyperpigmentation topical kojic acid is the more targeted, better-evidenced, and significantly lower-risk approach

Statistical analysis Statistical comparison samples previous and post- treatment, within and between groups were made using Graphpad Prism 6 (Version 6.01) software

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