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This vitamin is involved in forming DNA and red blood cells, as well as necessary for brain function, heart health, energy production, and more ( Its found naturally in many animal products and sometimes added to fortified foods ( Vegans, vegetarians, older adults, and people with digestive issues that can interfere with nutrient absorption may be at a higher risk of vitamin B12 deficiency and need to supplement ( summary Vitamin B12 is a water-soluble vitamin involved in several aspects of health, including DNA synthesis, red blood cell formation, and brain function
By activating downstream signaling pathways, IL-1 reduces the expression of key tight junction proteins, such as occludin and claudin-5, in BBB endothelial cells (101)
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Pediatr Blood Cancer 66:e27252 Hoban MD, Orkin SH, Bauer DE (2016) Genetic treatment of a molecular disorder: gene therapy approaches to sickle cell disease