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22 JNK activity correlates with Con A-induced hepatocyte damage

They observed that compared to the controls, the total antioxidant status was decreased, total oxidant status was increased, and markers of apoptosislike PARP-1 and Caspase-3 were elevated in the CBZ-treated group, leading to their conclusion that renal toxicity due to CBZ treatment occurs through oxidative stress-mediated apoptosis 19

reviewed by Schug et al., 2016)

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Owusu G, Obiri DD, Ainooson GK, Osafo N, Antwi AO, Duduyemi BM, Ansah C