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No significant effect was reported in measures of functional autonomy, mood, and behavioral disorders

The discussed studies were obtained from databases (PubMed, SciFinder), using the keyword Pycnogenol and placebo or double-blind. 2 Randomized, double-blind placebo-controlled human clinical studies with Pycnogenol The RDP human clinical studies conducted with Pycnogenol are summarized in Table 1, including a brief description of the study details and main findings