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These findings led to the investigation of the mechanism by which DSIP may alter mitochondrial activity in a hypoxic environment, suggesting that the peptide could also have an effect on the course of depression

Yuneva MO, Fan TWM, Allen TD, Higashi RM, Ferraris DV, Tsukamoto T, et al

Endoplasmic reticulum oxidoreductin 1-L (ERO1-L), a human gene induced in the course of the unfolded protein response

More importantly, our study shows that manipulating protein redox balance through GSH depletion in liver confers unexpected and substantial protection against MASLD