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Coumarin , L-leucine , and 3-indolepropionic acid emerged as top-ranking features based on mean decrease in accuracy, indicating their relative importance as diet-responsive metabolites within this cohort

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, Kim1 expression increased with higher doses of sulfasalazine (Supplemental Figure 6), suggesting a dose-dependent nephrotoxic effect

Biophys J 68(3):10271044 Chauveau C, Bonnemann CG, Julien C, Kho AL, Marks H, Talim B, Maury P, Arne-Bes MC, Uro-Coste E, Alexandrovich A, Vihola A, Schafer S, Kaufmann B, Medne L, Hbner N, Foley AR, Santi M, Udd B, Topaloglu H, Moore SA, Gotthardt M, Samuels ME, Gautel M, Ferreiro A (2014) Recessive TTN truncating mutations define novel forms of core myopathy with heart disease