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Using a L-5-methyltetrahydrofolate instead of folic acid, and ensuring we have optimal B12 in the form of methylcobalamin, and vitamin B6 in P-5-P form are key in helping with these pathways

This is a kind of end-product inhibition that prevents the GSH concentration from rising too high

Upon exposure to OGD/R, SH-SY5Y cells exhibited a marked upregulation of the proapoptotic proteins, Bax and caspase-3

doi: 10.1016/j.jconrel.2024.12.073 39 MonaliPFanSAlexJLLiangZThomasRNDebebeTet al

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